J. Saha

Defective Homologous Recombination and Genomic Instability Predict Increased Responsiveness to Carbon Ion Radiotherapy in Pancreatic Cancer

This study identifies PDAC cell lines defective in homologous recombination or with high genomic instability as more responsive to carbon ion radiotherapy, suggesting potential for targeted therapy.

Novel carbon nanoparticles derived from Bougainvillea modulate vegetative growth in Arabidopsis

This study synthesizes carbon nanoparticles from Bougainvillea species and shows their differential effects on Arabidopsis growth.

Sugar distributions on gangliosides guide the formation and stability of amyloid-β oligomers

This study shows that sugar distributions on gangliosides modulate Aβ oligomerization and stability.

De novo amyloid peptides with subtle sequence variations differ in their self-assembly and nanomechanical properties

Ganglioside enriched phospholipid vesicles induce cooperative Aβ oligomerization and membrane disruption

This study shows that GM1-enriched liposomes promote toxic Aβ oligomerization and membrane disruption through cooperative processes.

αS oligomers generated from polyunsaturated fatty acid and dopamine metabolite differentially interact with Aβ to enhance neurotoxicity

This study investigates how αS oligomers from DOPAL and DHA interact with Aβ, showing differential effects on Aβ aggregation and toxicity in neuroblastoma cells.

Ablating Ku70 phosphorylation results in defective DNA damage repair and spontaneous induction of hepatocellular carcinoma

This study shows that ablation of Ku70 phosphorylation leads to defective DNA repair and spontaneous hepatocellular carcinoma in mice.

A game theoretic approach to deciphering the dynamics of amyloid-β aggregation along competing pathways

This paper uses a game theoretic framework based on Nash equilibria to model and simulate competing pathways of amyloid-β aggregation in the presence of fatty acids, showing how rate constants control oligomer formation.