H. Lu

Non-Invasive Quality Control of Organoid Cultures Using Mesofluidic CSTR Bioreactors and High-Content Imaging

This paper develops a mesofluidic bioreactor platform with high-content imaging for non-invasive quality control of brain organoids, improving their development and reducing cell death.

Free energy profiles of temozolomide crossing brain plasma membranes

This paper investigates how temozolomide crosses brain plasma membranes using molecular dynamics simulations, finding that it cannot cross by pure diffusion at normal body temperature but requires higher temperatures or assistance from cholesterol and cerebroside lipids.

The Mammalian KU70 C-terminus SAP Domain Is Required to Repair Exogenous DNA Damage

This study shows that the KU70 SAP domain is essential for repairing exogenous DNA damage but not for V(D)J recombination or development.

Cyclin O controls entry into the cell-cycle variant required for multiciliated cell differentiation

Cyclin O is necessary for multiciliated cells to enter their differentiation cell cycle variant and allows the massive amplification of centrioles, which serve as basal bodies for cilia nucleation.

A safe insect-based Chikungunya fever vaccine affords rapid and durable protection in cynomolgus macaques

This study evaluates an insect-based chimeric virus vaccine against Chikungunya fever, showing rapid and durable protection in macaques.

Unraveling the impact of host genetics and factors on the urinary microbiome in a young population

This study characterizes the urinary microbiome in 1579 Chinese individuals, identifying host factors and genetic associations that influence microbial composition and urotype classification.

Neuromechanical Phase Lags and Gait Adaptation in the Nematode C. elegans

This study measures neuromechanical phase lags in C. elegans and shows they are controlled by body elasticity and environmental forces, shaping gait.

Defective Homologous Recombination and Genomic Instability Predict Increased Responsiveness to Carbon Ion Radiotherapy in Pancreatic Cancer

This study identifies PDAC cell lines defective in homologous recombination or with high genomic instability as more responsive to carbon ion radiotherapy, suggesting potential for targeted therapy.

Androgens modulate the immune profile in a mouse model of polycystic ovary syndrome

This study shows that androgen exposure in a mouse PCOS model alters immune cell populations in reproductive and metabolic tissues, with effects mediated through androgen receptors.

Directed biomechanical compressive forces enhance fusion efficiency in model placental trophoblast cultures

The paper shows that mechanical compressive forces enhance fusion in trophoblast cell cultures, suggesting a role for biomechanics in placental development.

Effects of Probiotics, Glucose Oxidase and its Combination on Immune Function, Antioxidant Status, Serum Biochemical Incides and Toxin Residue in Sheep when Challenged with Aflatoxin B1

This study evaluates how probiotics, glucose oxidase, and their combination affect sheep exposed to aflatoxin B1, improving health and reducing toxin levels.

Dissecting the Impact of Maternal Androgen Exposure on Offspring Health through Targeting the Androgen Receptor in Developmental Programming

This study investigates how maternal androgen exposure affects placental development in a PCOS-like mouse model and identifies trophoblast dysfunction as a key mechanism.

High-Throughput Evolution Unravels Landscapes of High-Level Antibiotic Resistance Induced by Low-Level Antibiotic Exposure

This study uses high-throughput evolution to explore antibiotic resistance landscapes in E. coli exposed to low-level antibiotics, identifying key mutations and developing predictive models.

Chaperone-mediated autophagy is an overlooked pathway for mutant alpha-1 antitrypsin Z degradation

This study identifies chaperone-mediated autophagy (CMA) as a key pathway for degrading mutant alpha-1 antitrypsin Z (ATZ), showing that enhancing CMA reduces ATZ accumulation in AATD.

Bacteriophages from human skin infecting coagulase-negative Staphylococcus: diversity, novel species and host resistance

The paper isolates and characterizes 40 bacteriophages from human skin that infect coagulase-negative Staphylococcus, identifying two novel species and host resistance mechanisms.

Liver-specific glucocorticoid action in alcoholic liver disease: study of glucocorticoid receptor knockout and knockin mice

This study investigates the role of liver-specific glucocorticoid receptor (GR) in alcoholic liver disease using knockout and knockin mice, finding that GR deficiency worsens steatosis and liver injury while GR overexpression provides protection.

Next-generation anti-PD-L1/IL-15 immunocytokine elicits superior antitumor immunity in cold tumors with minimal toxicity

This study introduces a next-generation immunocytokine, LH05, which shows improved antitumor effects in cold tumors with reduced toxicity compared to wild-type anti-PD-L1/IL-15.

Reprogramming Yarrowia lipolytica metabolism for efficient synthesis of itaconic acid from flask to semi-pilot scale

This study reprograms Yarrowia lipolytica metabolism to produce itaconic acid at high titres in bioreactors, offering a safer alternative to pathogenic fungal producers.

Automated cell annotation in multi-cell images using an improved CRF_ID algorithm

This paper improves the CRF_ID algorithm for multi-cell imaging in C. elegans, enhancing its accuracy and generalizability beyond whole-brain imaging.

Skin permeable polymer for noninvasive transdermal insulin delivery

This paper develops a polymer, OPDMA, that enables noninvasive transdermal insulin delivery in diabetic mice and minipigs, achieving hypoglycemic effects comparable to subcutaneous injection.

Pharmacological Induction of mesenchymal-epithelial transition chemosensitizes breast cancer cells and prevents metastatic progression

The paper shows that eribulin induces MET in mesenchymal-like TNBC cells, reducing metastatic potential and increasing sensitivity to other chemotherapeutics.

On-chip brain slice stimulation: precise control of electric fields and tissue orientation

This paper develops an on-chip platform for precise control of electric fields and tissue orientation in brain slice stimulation to better study the effects of direct current stimulation.

Single-Cell Map of Dynamic Multicellular Ecosystem of Radiation-Induced Intestinal Injury

This study maps the dynamic multicellular ecosystem of radiation-induced intestinal injury using single-cell RNA sequencing, revealing heterogeneous radiosensitivities and cellular interactions.

Zero-shot learning enables instant denoising and super-resolution in optical fluorescence microscopy

This paper introduces a zero-shot deep learning method for super-resolution microscopy that enhances resolution with less fluorescence and no training data.

Discovery and characterization of cross-reactive intrahepatic antibodies in severe alcoholic hepatitis

This study identifies cross-reactive intrahepatic antibodies in severe alcoholic hepatitis that target both bacterial antigens and human proteins, suggesting a role in disease pathogenesis.

Kinetics and efficacy of antibody drug conjugates in 3D tumour models

This study evaluates ADC efficacy in 3D tumor models, finding that spheroids are less sensitive to ADCs than monolayers, but ADCs can fully penetrate within 24h.

Development and optimisation of cationic lipid nanoparticles for mRNA delivery

This study develops and optimises cationic lipid nanoparticles for mRNA delivery in ovarian cancer cells, achieving 62% encapsulation efficiency and 9.4-fold transfection luminescence.

The role of B cells in immune cell activation in polycystic ovary syndrome

This study investigates the role of B cells in PCOS, finding that B cell frequency changes are driven by androgen receptor activation, but B cells are not essential for PCOS-like phenotype development.

Combined KRASG12C and SOS1 inhibition enhances and extends the anti-tumor response in KRASG12C-driven cancers by addressing intrinsic and acquired resistance

This study shows that combining KRASG12C and SOS1 inhibitors improves anti-tumor response and delays resistance in KRASG12C-driven cancers.

Spike substitution T813S increases Sarbecovirus fusogenicity by enhancing the usage of TMPRSS2.

The paper identifies the T813S mutation in the S2 subunit of SARS-CoV Spike protein enhances fusogenicity by improving TMPRSS2 cleavage, increasing viral replication.