Targeting fungal BET bromodomains as a pan-Candida antifungal strategy
K. Wei, J. M. Overhulse, M. Arlotto, Y. Zhou, N. J. Dupper, B. A. Kashemirov, C. Garnaud, G. Bourgine, M. Cornet, G. Rabut, C. E. McKenna, C. Petosa, J. Govin
This study identifies a phenyltriazine compound that selectively targets both Bdf1 bromodomains in Candida species, showing antifungal activity against multiple Candida strains including resistant isolates.
bioRxiv · Feb 3, 2023 · PreprintBiochemistry