Human bone marrow mesenchymal stem/stromal cell behaviour is coordinated via mechanically activated osteocyte-derived extracellular vesicles
K. Eichholz, I. Woods, G. Johnson, N. Shen, M. Corrigan, M.-N. Labour, K. Wynne, M. Lowery, L. O'Driscoll, D. A. Hoey
This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance human MSC recruitment and osteogenesis, suggesting their potential as a cell-free therapy for bone regeneration.
bioRxiv · Aug 8, 2019 · PreprintPhysiology