N. Shen

RNA interactome of hypervirulent Klebsiella pneumoniae reveals a small RNA inhibitor of capsular mucoviscosity and virulence

This study identifies ArcZ as a small RNA inhibitor of capsular hypermucoviscosity and virulence in hypervirulent Klebsiella pneumoniae through RNA interactome profiling.

The transcription factor Zeb2 drives differentiation of age-associated B cells

The paper identifies Zeb2 as a critical transcription factor driving age-associated B-cell differentiation and autoimmunity in humans and mice.

One-pot virus detection based on isothermal amplificationcoupled with temperature-activated argonaute

This paper develops a one-step virus detection method using immobilized thermotolerant Ago to separate amplification and cleavage steps, achieving high sensitivity and specificity.

NanoMOFs with Encapsulated Photosensitizer: Accumulation in Chlamydia trachomatis Inclusions and Antimicrobial Effects

This study demonstrates that iron-based nanoMOFs can co-localize with Chlamydia trachomatis in macrophages and exhibit antimicrobial effects through photodynamic inactivation and reduced bacterial load.

Mechanically activated bone cells drive vessel formation via an extracellular vesicle mediated mechanism

This study shows mechanically activated bone cells promote vessel formation through extracellular vesicles, which contain miRNAs linked to angiogenesis, offering a potential therapeutic for bone repair.

Siderophore-mediated iron partition promotes dynamical coexistence between cooperators and cheaters

The paper shows that siderophore-mediated iron partition enables stable coexistence between cheaters and partial cooperators in microbial communities.

Type 17 Follicular Helper T (Tfh17) Cells are Superior for Memory Maintenance

This study shows that Tfh17 cells are more effective than Tfh1 and Tfh2 cells in maintaining memory responses after vaccination.

Temporally integrated transcriptome analysis reveals ASFV pathology and host response dynamics

This study analyzes the temporal transcriptome changes in porcine macrophages infected with different ASFV strains to understand viral pathogenicity and host response dynamics.

Structural insights into the recognition of histone H3Q5 serotonylation by WDR5

This study identifies WDR5 as a reader of H3Q5ser, showing it binds to this modification and promotes transcription in neuroblastoma cells, suggesting a role in tumorigenesis.

A screening platform based on epitope editing for drug discovery

This paper introduces a drug discovery platform called SPEED that uses epitope editing to screen small molecules for altering antibody-epitope interactions and validates its application for Aβ species.

Human bone marrow mesenchymal stem/stromal cell behaviour is coordinated via mechanically activated osteocyte-derived extracellular vesicles

This study shows that mechanically activated osteocyte-derived extracellular vesicles enhance human MSC recruitment and osteogenesis, suggesting their potential as a cell-free therapy for bone regeneration.

Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells

This study identifies TGF-β1 signaling's role in chromatin remodeling that drives glycolysis in pathogenic TH17 cells through epigenetic regulation of metabolic regulators.

Human Retina-on-a-Chip: Merging Organoid and Organ-on-a-Chip Technology to Generate Complex Multi-Layer Tissue Models

This study develops a retina-on-a-chip model using hiPSC-derived retinal cells to recapitulate retinal interactions and test drug effects.

HDL-AuNPs-BMS nanoparticle conjugates as molecularly targeted therapy for leukemia

This paper develops HDL-AuNPs-BMS conjugates for leukemia treatment, showing enhanced drug delivery and epigenetic modulation in AML cells and mice.

T-bet+ CD11c+ B Cells Are Critical For Anti-Chromatin IgG Production In The Development Of Lupus