BiochemistrybioRxiv
METTL3 inhibitors for epitranscriptomic modulation of cellular processes
E. V. Moroz-Omori, D. Huang, R. K. Bedi…·A. Caflisch
This study identifies a METTL3 inhibitor, UZH1a, which reduces m6A methylation and inhibits leukemia cell growth, while its enantiomer UZH1b is inactive.
DOI 10.1002/cmdc.202100291