M. Danielson

Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies

This study shows that combining STING and TLR agonists enhances anti-tumor effects in mice, with synergistic responses observed when using bacterial pathogens and small molecule TLR agonists.

Host glutathione is required for Rickettsia parkeri to properly septate, avoid ubiquitylation, and survive in macrophages.

Dectin-1 Molecular Aggregation and Signaling is Sensitive to β-Glucan Structure and Glucan Exposure on Candida albicans Cell Walls

This study shows that Dectin-1A signaling and molecular aggregation depend on β-glucan structure and exposure, with higher structured glucans inducing more receptor dimerization and signaling.