MicrobiologybioRxivPreprint
Host glutathione is required for Rickettsia parkeri to properly septate, avoid ubiquitylation, and survive in macrophages.
DOI 10.1101/2023.10.02.560592
Author
T. P. Burke
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2019-2023 · peak 2/yrCo-Author Collaboration Network
10 top collaborators · 22 mutual co-author linksFocal author (center)Selected co-authorORCID co-authorUnlinked name
Curved chords = mutual co-authorship5 papers
Recent·Most cited
- MicrobiologybioRxiv
A patatin-like phospholipase mediates Rickettsia parkeri escape from host membranes
G. M. Borgo, T. P. Burke, C. J. Tran…·M. D. Welch
This study identifies Pat1, a patatin-like phospholipase in Rickettsia parkeri, as critical for escaping host membranes and promoting cell-cell spread during infection.
- MicrobiologybioRxiv
Lysine methylation shields an intracellular pathogen from ubiquitylation
P. Engstrom, T. P. Burke, A. T. Iavarone, M. D. Welch
This study shows that Rickettsia parkeri uses lysine methylation to prevent ubiquitylation of outer membrane proteins, thereby evading host autophagy and enabling pathogenesis.
DOI 10.1126/sciadv.abg2517 - MicrobiologybioRxiv
Interferon receptor-deficient mice are susceptible to eschar-associated rickettsiosis.
T. P. Burke, P. Engstrom, C. J. Tran…·M. D. Welch
This study shows that interferon receptor-deficient mice develop eschars and lethal disease upon Rickettsia parkeri infection, mimicking human rickettsiosis, and identifies vaccine candidates.
DOI 10.7554/elife.67029 - ImmunologybioRxiv
Inflammasome-mediated antagonism of type I interferon enhances Rickettsia pathogenesis
T. P. Burke, P. Engström, R. A. Chavez…·M. D. Welch
This study shows that Rickettsia parkeri is sensitive to type I interferon, which is counteracted by inflammasome-mediated pyroptosis, revealing a trade-off in innate immunity.
DOI 10.1038/s41564-020-0673-5