CRISPR-based bioengineering of the Transferrin Receptor revealed a role for Rab7 in the biosynthetic secretory pathway
M. Deffieu, I. Cesonyte, F. Delalande, G. Boncompain, C. Dorobantu, E. Song, V. Lucansky, A. Hirschler, S. Cianferani, T. Xu, F. Perez, C. Carapito, R. Gaudin
The paper uses CRISPR-based bioengineering to study TfR trafficking and identifies Rab7 as an intermediate compartment in the Golgi-to-PM transport of neosynthetic TfR.
bioRxiv · Jan 5, 2020 · PreprintCell Biology