G. Boncompain

A fluorogenic chemically induced dimerization technology for controlling, imaging and sensing protein proximity

This paper introduces CATCHFIRE, a chemically induced dimerization technology that enables real-time monitoring of protein proximity with fluorescence imaging and sensing capabilities.

Regulation of cell dynamics by rapid transport of integrins through the biosynthetic pathway

This study shows that integrin transport through the biosynthetic pathway rapidly alters adhesion receptor availability, enabling localized cell spreading and focal adhesion growth.

Regulation of neuronal progenitor delamination by dynein-driven post-Golgi apical transport

This study identifies a RAB6-dynein-LIS1 complex that regulates apical transport in radial glial cells, essential for maintaining neuroepithelial integrity and proper brain development.

Specificities of exosome versus small ectosome secretion revealed by live intracellulartracking and synchronized extracellular vesicle release of CD9 and CD63

This study compares exosome and small ectosome secretion in HeLa cells using live tracking and proteomic analysis, revealing differences in their trafficking and release mechanisms.

Dendritic cells require TMEM176A/B ion channels for optimal MHC II antigen presentation to naive CD4+ T cells

The paper shows TMEM176A/B ion channels are essential for dendritic cells to present antigens to CD4+ T cells, but not for Th17 or ILC3 function.

CRISPR-based bioengineering of the Transferrin Receptor revealed a role for Rab7 in the biosynthetic secretory pathway

The paper uses CRISPR-based bioengineering to study TfR trafficking and identifies Rab7 as an intermediate compartment in the Golgi-to-PM transport of neosynthetic TfR.

The Glyco-enzyme adaptor GOLPH3 Links Intra-Golgi Transport Dynamics to Glycosylation Patterns and Cell Proliferation

This study shows GOLPH3 regulates glycosylation and cell proliferation by controlling glyco-enzyme recycling and lysosomal degradation.

CHC22 clathrin mediates traffic from early secretory compartments for human GLUT4 pathway biogenesis

The paper identifies CHC22 clathrin as mediating ERGIC-derived membrane traffic essential for GLUT4 sequestration in humans, distinct from mice lacking CHC22.

RAB6 and microtubules restrict secretion to focal adhesions

The paper shows that RAB6 and microtubules direct secretion to focal adhesions by restricting exocytosis to localized hotspots.

Differential screening identifies molecules specifically inhibiting CCR5 transport to the cell surface and HIV infection

The paper identifies molecules that inhibit CCR5 transport to the cell surface and HIV infection by targeting palmitoylation.