Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation
M. Devos, G. Tanghe, B. Gilbert, E. Dierick, M. Verheirstraeten, J. Nemegeer, R. de Reuver, S. Lefebvre, J. De Munck, J. Rehwinkel, P. Vandenabeele, W. Declercq, J. Maelfait
The paper shows that ZBP1 sensing of endogenous nucleic acids causes necroptosis and skin inflammation in RIPK1-deficient keratinocytes, linked to IL-17 immune responses.
bioRxiv · Mar 25, 2020Immunology