Author

J. Maelfait

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Organism:mouse· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

E. Dierick· 2 shared J. Rehwinkel· 2 shared P. Vandenabeele· 2 shared R. de Reuver· 2 shared A. Botzki· 1 shared A. Oberst· 1 shared B. Gilbert· 1 shared B. Lambrecht· 1 shared

Activity by Year

2020-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

E. Dierick

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

ZBP1 induces inflammatory signaling via RIPK3 and promotes SARS-CoV-2-induced cytokine expression

R. Peng, X. Wang-Kan, M. Idorn, F. Y. Zhou, S. L. Orozco, J. McCarthy, C. S. Leung, X. Lu, K. Bagola, J. Rehwinkel, A. Oberst, J. Maelfait, S. R. Paludan, M. Gyrd-Hansen

This study identifies a ZBP1-RIPK1-RIPK3 pathway that promotes SARS-CoV-2-induced cytokine expression through inflammatory signaling independent of cell death.

bioRxiv · Oct 1, 2021 · PreprintImmunology

ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.

R. de Reuver, E. Dierick, B. Wiernicki, K. Staes, L. Seys, E. De Meester, T. Muyldermans, A. Botzki, B. Lambrecht, F. Van Nieuwerburgh, P. Vandenabeele, J. Maelfait

This study shows that ADAR1's interaction with Z-RNA reduces A-to-I editing of self-dsRNA, leading to MDA5-dependent immune activation and AGS in mutant cells and mice.

bioRxiv · Dec 4, 2020Immunology

Sensing of endogenous nucleic acids by ZBP1 induces keratinocyte necroptosis and skin inflammation

M. Devos, G. Tanghe, B. Gilbert, E. Dierick, M. Verheirstraeten, J. Nemegeer, R. de Reuver, S. Lefebvre, J. De Munck, J. Rehwinkel, P. Vandenabeele, W. Declercq, J. Maelfait

The paper shows that ZBP1 sensing of endogenous nucleic acids causes necroptosis and skin inflammation in RIPK1-deficient keratinocytes, linked to IL-17 immune responses.

bioRxiv · Mar 25, 2020Immunology