ADAR1 interaction with Z-RNA promotes editing of endogenous double-stranded RNA and prevents MDA5-dependent immune activation.
R. de Reuver, E. Dierick, B. Wiernicki, K. Staes, L. Seys, E. De Meester, T. Muyldermans, A. Botzki, B. Lambrecht, F. Van Nieuwerburgh, P. Vandenabeele, J. Maelfait
This study shows that ADAR1's interaction with Z-RNA reduces A-to-I editing of self-dsRNA, leading to MDA5-dependent immune activation and AGS in mutant cells and mice.
bioRxiv · Dec 4, 2020Immunology