Author

M. E. Hegi

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

R. T. Daniel· 2 shared A. Hottinger· 1 shared A. Salamero-Boix· 1 shared A. Schaeffer· 1 shared B. T. Elie· 1 shared C. Cudalbu· 1 shared F. Klemm· 1 shared J. A. Joyce· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

R. T. Daniel

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Author profile →

2 papers

Recent·Most cited

Metabolic and transcriptomic profiles of glioblastoma invasion revealed by comparisons between patients and corresponding orthotopic xenografts in mice

C. Cudalbu, P. Bady, M. Lai, L. Xin, O. Gusyatiner, M.-F. Hamou, M. Lepore, J.-P. Brouland, R. T. Daniel, A. Hottinger, M. E. Hegi

This study compares metabolic and transcriptomic profiles of glioblastoma in patient tumors and orthotopic xenografts in mice to identify invasion-related molecular signatures.

Acta Neuropathologica Communications · Aug 4, 2021Peer-reviewedCancer Biology

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F. Klemm, A. Schaeffer, A. Salamero-Boix, T. Alekseeva, M. Schulz, K. Niesel, R. R. Maas, M. Groth, B. T. Elie, R. L. Bowman, M. E. Hegi, R. T. Daniel, P. S. Zeiner, J. Zinke, P. N. Harter, , L. Sevenich

The paper shows that blocking CSF1R in brain metastases initially reduces tumor growth but is ineffective in established tumors due to compensatory macrophage activation, which is overcome by combining CSF1R and STAT5 inhibition.

bioRxiv · Jun 7, 2021Cancer Biology