Author

L. Sevenich

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

P. N. Harter· 2 shared P. S. Zeiner· 2 shared T. Alekseeva· 2 shared A. Salamero-Boix· 1 shared A. Schaeffer· 1 shared A.-L. Luger· 1 shared B. Sauer· 1 shared B. T. Elie· 1 shared

Activity by Year

2021-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersCancer Biology

P. N. Harter

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2 papers

Recent·Most cited

AMP-kinase mediates adaptation of glioblastoma cells to conditions of the tumour microenvironment

N. I. Lorenz, B. Sauer, P. S. Zeiner, M. I. Strecker, A.-L. Luger, D. Schulte, M. Mittelbronn, T. Alekseeva, L. Sevenich, P. N. Harter, C. Münch, J. P. Steinbach, M. W. Ronellenfitsch

This study shows that AMPK is essential for glioblastoma cells to adapt to low energy conditions in the tumor microenvironment, with AMPK inhibition reducing tumor growth and mitochondrial function.

bioRxiv · Mar 25, 2022 · PreprintCancer Biology

Compensatory CSF2-driven macrophage activation promotes adaptive resistance to CSF1R inhibition in breast-to-brain metastasis

F. Klemm, A. Schaeffer, A. Salamero-Boix, T. Alekseeva, M. Schulz, K. Niesel, R. R. Maas, M. Groth, B. T. Elie, R. L. Bowman, M. E. Hegi, R. T. Daniel, P. S. Zeiner, J. Zinke, P. N. Harter, , L. Sevenich

The paper shows that blocking CSF1R in brain metastases initially reduces tumor growth but is ineffective in established tumors due to compensatory macrophage activation, which is overcome by combining CSF1R and STAT5 inhibition.

bioRxiv · Jun 7, 2021Cancer Biology