M. F. Boni

Age-dependent heterogeneity in the antigenic effects of mutations to influenza hemagglutinin

The paper maps how HA mutations affect neutralization by serum from different age groups, showing age-dependent antigenic effects and implications for viral evolution.

Assessing emergence risk of double-resistant and triple-resistant genotypes of Plasmodium falciparum

This study compares MFT and cycling policies for ACT deployment, finding MFT reduces multi-drug resistance risk by 4-90% in areas with ≥1% PfPR.

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

Antimalarial mass drug administration in large populations and the evolution of drug resistance

This study evaluates how mass drug administration (MDA) can accelerate drug resistance in large populations under specific conditions and highlights the importance of post-MDA case management.

Natural selection in the evolution of SARS-CoV-2 in bats, not humans, created a highly capable human pathogen

The paper shows SARS-CoV-2's ability to infect humans stems from its evolutionary history in bats, not human adaptation, with evidence of positive selection in bat viruses and weak purifying selection in SARS-CoV-2.

Evolutionary origins of the SARS-CoV-2 sarbecovirus lineage responsible for the COVID-19 pandemic

This paper estimates the divergence date of SARS-CoV-2 from its bat reservoir to be between 1948 and 1982, identifies non-recombinant regions for phylogenetic analysis, and highlights the role of horseshoe bats in viral emergence.