Author

H. Tegally

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Evolutionary Biology· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Approach:experimental assay· 1 Assay:imaging· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

T. de Oliveira· 3 shared A. Sigal· 2 shared C. Williamson· 2 shared J. Giandhari· 2 shared A. De Klerk· 1 shared A. G. Lucaci· 1 shared A. Iranzadeh· 1 shared A. J. Greaney· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersEvolutionary Biology

T. de Oliveira

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Selection analysis identifies unusual clustered mutational changes in Omicron lineage BA.1 that likely impact Spike function

D. P. Martin, S. Lytras, A. G. Lucaci, W. Maier, B. Gruning, S. D. Shank, S. Weaver, O. S. MacLean, R. J. Orton, P. Lemey, M. F. Boni, H. Tegally, G. W. Harkins, C. Scheepers, J. N. Bhiman, , S. L. Kosakovsky Pond

The paper identifies 13 rare mutations in the Omicron S-gene that cluster in functionally important regions and likely impact Spike function, suggesting cooperative interactions that mitigate fitness costs.

bioRxiv · Jan 14, 2022 · PreprintEvolutionary Biology

SARS-CoV-2 cell-to-cell spread occurs rapidly and is insensitive to antibody neutralization

L. Jackson, H. Rodel, S.-H. Hwa, S. Cele, Y. Ganga, H. Tegally, M. Bernstein, J. Giandhari, COMMIT-KZN Team, B. I. Gosnell, K. Khan, W. Hanekom, F. Karim, T. de Oliveira, M.-Y. S. Moosa, A. Sigal

This study shows SARS-CoV-2 spreads rapidly between cells via fusion and is resistant to antibody neutralization, unlike cell-free virus.

bioRxiv · Jun 1, 2021 · PreprintMicrobiology

SARS-CoV-2 501Y.V2 (B.1.351) elicits cross-reactive neutralizing antibodies

T. Moyo-Gwete, M. Madzivhandila, Z. Makhado, F. Ayres, D. Mhlanga, B. Oosthuysen, B. Lambson, P. Kgagudi, H. Tegally, A. Iranzadeh, D. Doolabh, L. Tyers, L. Chinhoyi, M. Mennen, S. Skelem, , P. Moore

This study examines antibody responses to the SARS-CoV-2 501Y.V2 variant in patients hospitalized in early 2021, finding robust cross-reactivity against earlier variants and the 501Y.V3 variant.

bioRxiv · Mar 6, 2021 · PreprintImmunology