MAP Kinase inhibition reshapes tumor microenvironment of mouse pancreatic cancer by depleting anti-inflammatory macrophages
P. Delfino, C. Neander, D. Filippini, S. D'Agosto, C. Vicentini, E. Fiorini, F. Lupo, C. Fiorini, B. Rusev, G. Temgue Tane, F. De Sanctis, M. Simbolo, S. Ugel, V. Bronte, M. Fassan, , V. Corbo
This study shows that MEK inhibition in mouse pancreatic cancer reduces anti-inflammatory macrophages and enhances gemcitabine efficacy by altering the tumor microenvironment.
bioRxiv · Sep 8, 2019 · PreprintCancer Biology