F. Lupo

Differential Activity of MAPK signalling Defines Fibroblast Subtypes in Pancreatic Cancer

This study identifies MAPK signalling as defining fibroblast subtypes in pancreatic cancer, linking MAPKhigh CAFs to poor prognosis and immune evasion.

ecDNA amplification of MYC drives intratumor copy-number heterogeneity and adaptation to stress in PDAC

The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC

This study shows SEMA3A promotes aggressive basal-like PDAC by enhancing metastasis and modulating the tumor microenvironment through macrophage polarization and T cell exclusion.

The immune system fails to mount a protective response to Gram-positive or Gram-negative bacterial prostatitis

This study shows that immune responses to bacterial prostatitis do not prevent reinfection, as bacterial burden remains high despite adaptive immune activation.

MAP Kinase inhibition reshapes tumor microenvironment of mouse pancreatic cancer by depleting anti-inflammatory macrophages

This study shows that MEK inhibition in mouse pancreatic cancer reduces anti-inflammatory macrophages and enhances gemcitabine efficacy by altering the tumor microenvironment.