The axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC
F. Lupo, F. Pezzini, E. Fiorini, A. Adamo, L. Veghini, M. Bevere, C. Frusteri, P. Delfino, S. D'Agosto, S. Andreani, G. Piro, A. Malinova, F. De Sanctis, D. Pasini, R. T. Lawlor, , V. Corbo
This study shows SEMA3A promotes aggressive basal-like PDAC by enhancing metastasis and modulating the tumor microenvironment through macrophage polarization and T cell exclusion.
bioRxiv · Feb 25, 2023Cancer Biology