A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ
C. P. McEntee, S. Houston, C. M. Finlay, S. Rossi, G. Liu, T. N. Shaw, J. Casulli, M. Fife, C. Smedley, T. S. Griffith, M. Pepper, T. Hussell, P. M. Hansbro, J.-M. Schwartz, H. Paidassi, M. A. Travis
The paper identifies a subset of CD4+ effector memory T cells that limit secondary immune responses to viral re-infection and prevent lung pathology by activating latent TGFβ.
bioRxiv · Mar 2, 2023 · PreprintImmunology