M. Pepper

Monoclonal antibodies derived from B cells in subjects with cystic fibrosis reduce Pseudomonas aeruginosa burden in mice

The paper isolates PcrV-specific B cells from cystic fibrosis patients and generates monoclonal antibodies that reduce Pseudomonas aeruginosa burden in mice.

A subset of CD4+ effector memory T cells limit immunity to pulmonary viral infection and prevent tissue pathology via activation of latent TGFβ

The paper identifies a subset of CD4+ effector memory T cells that limit secondary immune responses to viral re-infection and prevent lung pathology by activating latent TGFβ.

IL-4 downregulates BCL6 to promote memory B cell selection in germinal centers

This study shows IL-4 downregulates BCL6 in GC B cells to promote memory B cell selection and regulate affinity maturation.

Plasmodium infection disrupts the T follicular helper cell response to heterologous immunization

This study shows that Plasmodium infection impairs T follicular helper cell responses to heterologous immunization, despite functional dendritic cells.

Elicitation of potent neutralizing antibody responses by designed protein nanoparticle vaccines for SARS-CoV-2

This study designs SARS-CoV-2 nanoparticle vaccines that induce strong neutralizing antibodies in mice, with higher titers and lower doses than existing trimer vaccines.