MET variants with activating N-lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation
C. M. Guerin, A. Vinchent, M. Fernandes, I. Damour, A. Laratte, R. Tellier, G. O. Estevam, J.-P. Meneboo, C. Villenet, C. Descarpentries, J. S. Fraser, M. Figeac, A. B. Cortot, E. Rouleau, D. Tulasne
This paper identifies N-lobe MET mutations in HPRCC that require ligand stimulation for activation, unlike kinase domain mutations, and shows their sensitivity to MET inhibitors.
bioRxiv · Nov 3, 2023Cancer Biology