Author

J.-C. Sirard

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

J.-W. Veening· 3 shared X. Liu· 3 shared C. Costa· 2 shared J. Denereaz· 2 shared L. Matarazzo· 2 shared M. Baldry· 2 shared V. de Bakker· 2 shared A. Domenech· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMicrobiology

J.-W. Veening

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Author profile →

4 papers

Recent·Most cited

MicrobiologybioRxivPreprintJul 7, 2023

A conserved antigen induces respiratory Th17-mediated serotype-independent protection against pneumococcal superinfection

X. Liu, L. Van Maele, L. Matarazzo…·J.-W. Veening

The paper identifies a conserved antigen, LafB, that provides serotype-independent protection against pneumococcal superinfection via Th17 cells, independent of antibodies.

DOI 10.1101/2023.07.07.548156

mouseexperimental assay

𝕏 PostBluesky

MicrobiologybioRxivPreprintAug 3, 2022

Competence remodels the pneumococcal cell wall providing resistance to fratricide and surface exposing key virulence factors

V. Minhas, A. Domenech, D. Synefiaridou…·J.-W. Veening

This study shows that competence in Streptococcus pneumoniae is crucial for virulence by increasing surface exposure of virulence factors and providing resistance to fratricide.

DOI 10.1101/2022.08.03.502730

humanproteomics

𝕏 PostBluesky

MicrobiologybioRxivSep 13, 2021

Amoxicillin-resistant Streptococcus pneumoniae can be resensitized by targeting the mevalonate pathway as indicated by sCRilecs-seq

L. Dewachter, X. Liu, J. Denereaz…·J.-W. Veening

This paper identifies the mevalonate pathway as a target to resensitize amoxicillin-resistant Streptococcus pneumoniae using sCRilecs-seq.

DOI 10.7554/elife.75607

humanCRISPR screen

𝕏 PostBluesky

MicrobiologybioRxivPreprintFeb 18, 2020

Boosting Toll-like receptor 4 signaling enhances the therapeutic outcome of antibiotic therapy in pneumococcal pneumonia

F. Casilag, S. Franck, L. Matarazzo…·J.-C. Sirard

This study shows that combining TLR4 activation with antibiotics improves bacterial clearance and survival in pneumococcal pneumonia.

DOI 10.1101/2020.02.18.955500

mousebulk RNA-seq

𝕏 PostBluesky