The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease
R. T. Bishop, A. K. Miller, M. Froid, N. Nerlakanti, T. Li, J. Frieling, M. Nasr, K. Nyman, P. Sudalagunta, R. Canevarolo, A. S. Silva, K. T. Shain, C. Lynch, D. Basanta
This study uses a hybrid agent-based model to show the bone ecosystem promotes multiple myeloma relapse and the evolution of proteasome inhibitor-resistant disease by providing a protective niche for drug-sensitive cells.
bioRxiv · Nov 13, 2022 · PreprintCancer Biology