T. Li

Incentive valence differentially engages open- and closed-loop basal ganglia circuits during movement initiation

The paper investigates how incentive valence engages different basal ganglia circuits during movement initiation, finding distinct neural patterns for reward and threat conditions.

Cyclin-dependent kinase 9 inhibitors as oncogene signaling modulators in combination with targeted therapy for the treatment of colorectal cancer

This study evaluates CDK9 inhibitors in CRC models, showing potent anti-proliferative effects and synergy with MEK inhibitors, suggesting a potential combination therapy for CRC.

Nuclear regulatory disturbances precede and predict the development of Type-2 diabetes in Asian populations

The paper identifies DNA methylation biomarkers predictive of Type-2 diabetes in Asian populations and shows their utility in risk stratification.

An emerging PB2-627 polymorphism increases the pandemic potential of avian influenza virus by breaking through ANP32 host restriction in mammalian and avian hosts

This paper identifies a PB2-627V mutation in avian influenza viruses that enhances pandemic potential by overcoming host restriction through ANP32A proteins in both avian and mammalian hosts.

Structural basis of the human transcriptional Mediator complex modulated by its dissociable Kinase module

This study presents cryo-EM structures of the human Mediator complex and its CKM module, revealing how the CKM inhibits transcription by blocking Pol II and PIC assembly.

Microsporidian Nosema bombycis secretes serine protease inhibitor to suppress host cell apoptosis via caspase BmICE

This paper identifies NbSPN14, a serine protease inhibitor secreted by Nosema bombycis, which inhibits host cell apoptosis by interacting with BmICE, providing insights into pathogen-host interactions.

Structure-Mechanics Principles and Mechanobiology of Fibrocartilage Pericellular Matrix: A Pivotal Role of Type V Collagen

This study investigates the structure-mechanical properties and mechanobiological functions of the pericellular matrix in fibrocartilage, highlighting the critical role of collagen V in maintaining its integrity and function.

Multi-step engineered adeno-associated virus enables whole-brain mRNA delivery

This paper develops a system to package mRNAs into AAVs, enabling efficient whole-brain mRNA delivery in mice.

Urea amidolyase as the enzyme for urea utilization in algae: functional display in Chlamydomonas reinhardtii and evolution in algae

This study identifies urea amidolyase (UAD) as the key enzyme for urea utilization in algae, showing its functional importance and evolutionary distribution in Chlamydomonas reinhardtii.

Exogenous myristate fuels the growth of symbiotic arbuscular mycorrhizal fungi but disrupts their carbon-phosphorus exchange with host plants

This study shows that exogenous myristate supports AMF growth but reduces phosphorus transfer to host plants, suggesting it may hinder symbiosis.

FLASH Irradiation Regulates IFN-β induction by mtDNA via Cytochrome c Leakage

This study shows FLASH irradiation increases cytochrome c leakage from mitochondria in normal cells, reducing mtDNA accumulation and IFN-β secretion, while having the opposite effect in cancer cells.

Adaptive Functions of Structural Variants in Human Brain Development

This study identifies human-specific structural variants in rhesus macaques, showing their impact on human brain development through gene expression changes.

Virological characteristics of SARS-CoV-2 Omicron BA.5.2.48

This study evaluates the virological characteristics of BA.5.2.48 subvariant isolates, finding enhanced transmission and pathogenicity compared to BA.2, with divergent features among subvariants.

Hepatitis E virus infection upregulates ING5 expression in vitro and vivo

This study shows that HEV infection increases ING5 expression in both animal models and human cells, suggesting a potential role in HEV pathogenesis.

The origin and evolution of cultivated rice and genomic signatures of heterosis for yield traits in super-hybrid rice

This study investigates the evolutionary history of cultivated rice and identifies genomic signatures of heterosis in super-hybrid rice varieties.

A physically inspired approach to coarse-graining transcriptomes reveals the dynamics of aging: multiscale description of gene expressions and a spectral view of aging dynamics

This study applies physics-inspired methods to single-cell RNA sequencing data to uncover multiscale patterns in aging transcriptomes and provides a spectral view of aging dynamics.

Physical basis for the interaction between Drosophila ROS1 and the GPCR BOSS

This study determines the structure of Drosophila ROS1's extracellular region bound to BOSS, revealing a hydrophobic interaction and beta-strand augmentation mechanism.

Glioma-associated fibroblasts promote glioblastoma resistance to temozolomide through CCL2-CCR2 paracrine signaling

This paper shows that glioma-associated fibroblasts enhance glioblastoma resistance to temozolomide by secreting CCL2, which activates the ERK1/2 pathway in cancer cells.

Ubiquitin-mediated stabilization of SlPsbS regulates low night temperature tolerance in tomatoes

This study identifies a ubiquitin-mediated degradation pathway involving SlCV and SlCSN5A that regulates SlPsbS stability under low night temperatures in tomatoes.

ATP13A1 engages GET3 to facilitate substrate-specific translocation

The paper shows ATP13A1 uses GET3 to translocate cleaved signal sequences to the ER in a substrate-specific manner, ensuring efficient and accurate protein localization.

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

Transcriptomic and epigenetic responses shed light on soybean resistance to Phytophthora sansomeana

This study examines transcriptomic and epigenetic responses in soybean lines resistant and susceptible to Phytophthora sansomeana, identifying key genes and regulatory mechanisms involved in defense.

Discovery of the 1-naphthylamine biodegradation pathway reveals an enzyme that catalyzes 1-naphthylamine glutamylation

The paper identifies a bacterial pathway for degrading 1-naphthylamine, revealing an enzyme that catalyzes its glutamylation and elucidates the mechanism and evolution of the pathway.

Blocker-SELEX: A Structure-guided Strategy for Developing Inhibitory Aptamers Disrupting Undruggable Transcription Factor Interactions

This paper introduces Blocker-SELEX, a structure-guided method to design inhibitory aptamers that disrupt transcription factor interactions, demonstrating efficacy against SCAF4/SCAF8-RNAP2 and WDR5-MYC complexes.

The sea urchin Paracentrotus lividus orients to visual stimuli

This study shows that the sea urchin Paracentrotus lividus can orient to visual stimuli with coarse spatial resolution, using a model adapted from another species to predict its angular sensitivity.

Neu5Gc binding loss of subtype H7 influenza A virus facilitates adaptation to gallinaceous poultry following transmission from waterbirds but restricts spillback

This study shows H7 influenza A viruses lose Neu5Gc binding during adaptation to chickens, enhancing transmissibility in poultry but reducing transmission back to wild birds.

Discrimination of Isomeric Glycans via High-sensitive Engineered Nanopore

This paper designs an engineered nanopore to distinguish isomeric glycans with high sensitivity and achieves over 90% separation accuracy without machine learning.

Single cell transcriptomics reveals chondrocyte differentiation dynamics in vivo and in vitro

This study uses single-cell transcriptomics to compare in vitro and in vivo chondrocyte differentiation, identifies off-target differentiation, and improves in vitro protocols by inhibiting FOXO1.

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

Inhibition of O-GlcNAc transferase activates type I interferon-dependent antitumor immunity by bridging cGAS-STING pathway

This study shows that inhibiting OGT activates type I interferon-dependent antitumor immunity by enhancing the cGAS-STING pathway through genomic instability.