D. Basanta

Peristromal niches protect lung cancers from targeted therapies through a combined effect of multiple molecular mediators

This study shows that stromal niches protect lung cancers from ALK inhibitors through multiple mechanisms, and targeting these mechanisms together is more effective than targeting them individually.

Paracrine enhancement of tumor cell proliferation provides indirect stroma-mediated chemoresistance via acceleration of tumor recovery between chemotherapy cycles.

The paper investigates how stromal factors indirectly enhance tumor chemoresistance by accelerating tumor recovery between chemotherapy cycles through paracrine signaling.

The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease

This study uses a hybrid agent-based model to show the bone ecosystem promotes multiple myeloma relapse and the evolution of proteasome inhibitor-resistant disease by providing a protective niche for drug-sensitive cells.

Integrated computational and in vivo models reveal Key Insights into Macrophage Be-havior during bone healing

This study uses a mathematical framework to analyze bone healing dynamics, revealing roles of pro- and anti-inflammatory macrophages in osteoclast and osteoblast behavior.

Understanding the Evolutionary Games in NSCLC Microenvironment

The paper uses evolutionary game theory to study non-cell autonomous resistance mechanisms in NSCLC, showing HGF-producing cells outcompete others and support therapy-naive cells.

Computational modeling reveals a key role for polarized myeloid cells in controlling osteoclast activity during bone injury repair

The paper uses an ODE model to show that pro- and anti-inflammatory myeloid cells are essential for bone repair by regulating osteoclast activity beyond just osteoblast/osteoclast numbers.

High school Internship Program in Integrated Mathematical Oncology (HIP IMO) - five-year experience at Moffitt Cancer Center

The paper describes a high school internship program in mathematical oncology, detailing its structure, curriculum, and outcomes over five years.

What is the storage effect, why should it occur in cancers, and how can it inform cancer therapy?

The paper explores the storage effect as a mechanism for intratumor heterogeneity, arguing that it may explain cancer diversity and inform therapy.

Spontaneous Cell Fusions as a Mechanism of Parasexual Recombination in Tumor Cell Populations

This study investigates spontaneous cell fusions in tumor cell populations as a mechanism of parasexual recombination, finding evidence of low-frequency fusions and their role in increasing clonal heterogeneity.

Selection-driven tumor evolution involving non-cell growth promotion leads to patterns of clonal expansion consistent with neutrality interpretation

This study uses agent-based modeling to show that tumor evolution driven by space acquisition and proliferation can produce clonal patterns resembling neutral evolution.

Hypoxia increases the tempo of evolution in glioblastoma

This study shows hypoxia accelerates tumour evolution by increasing cell division and mutation rates in glioblastoma.

Modelling Osteocyte Network Formation: Healthy and Cancerous Environments

This paper develops a stochastic agent-based model to simulate osteocyte network formation in healthy and cancerous bone environments, revealing how cancer and therapies alter network structure and density.

Hybrid Automata Library: A modular platform for efficient hybrid modeling with real-time visualization

The paper introduces the Hybrid Automata Library (HAL), a Java platform for building hybrid models in mathematical oncology, with real-time visualization and modular components.

Fibroblasts and Alectinib switch the evolutionary games played by non-small cell lung cancer

The paper develops a game assay to measure evolutionary games in cancer cell co-cultures, showing that fibroblasts and Alectinib shift the game type from Leader to Deadlock.

Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer

This paper introduces a model showing that fractionated follow-up chemotherapy delays resistance onset in bone metastatic prostate cancer compared to continuous or periodic schedules.

Size Matters: Metastatic cluster size and stromal recruitment in the establishment of successful prostate cancer to bone metastases

This study uses a computational model to show that prostate cancer metastases to bone require optimal cluster size and stromal cell recruitment for successful establishment.

Homeostasis Back and Forth: An Eco-Evolutionary Perspective of Cancer

The paper discusses how cancer cells disrupt tissue homeostasis and proposes an eco-evolutionary framework to understand tumor progression and treatment.