C. Lynch

First endangered black-footed ferrets, Mustela nigripes, cloned for genetic rescue

Researchers cloned an endangered black-footed ferret using cross-species somatic cell nuclear transfer, producing three healthy kits to aid genetic rescue.

The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease

This study uses a hybrid agent-based model to show the bone ecosystem promotes multiple myeloma relapse and the evolution of proteasome inhibitor-resistant disease by providing a protective niche for drug-sensitive cells.

Quantitative bioactivity signatures of dietary supplements and natural products

The paper screens dietary supplements and natural products for bioactivity using in vitro assays and predicts their mechanisms of action by comparing activity profiles with approved drugs.

Integrated computational and in vivo models reveal Key Insights into Macrophage Be-havior during bone healing

This study uses a mathematical framework to analyze bone healing dynamics, revealing roles of pro- and anti-inflammatory macrophages in osteoclast and osteoblast behavior.

Water Nanoconfined in a Hydrophobic Pore: MD Simulations and Water Models

This study uses molecular dynamics simulations to show that polarisable water models enhance wettability in hydrophobic nanopores, affecting wetting/de-wetting behavior in ion channels.

Conversion of mammalian cell culture media waste to microbial fermentation feed efficiently supports production of recombinant protein by Escherichia coli

This study shows that spent cell culture media can be reused as a feed for microbial fermentation to produce recombinant proteins with performance comparable to standard media.

A Library Of Induced Pluripotent Stem Cells From Clinically Well-Characterized, Diverse Healthy Human Individuals

The paper generates and characterizes a diverse library of hiPSCs from healthy humans for use in disease modeling and drug response studies.

Apoptosis, G1 phase stall and premature differentiation account for low chimeric competence of Human and rhesus monkey naive pluripotent stem cells

Fractionated follow-up chemotherapy delays the onset of resistance in bone metastatic prostate cancer

This paper introduces a model showing that fractionated follow-up chemotherapy delays resistance onset in bone metastatic prostate cancer compared to continuous or periodic schedules.

Size Matters: Metastatic cluster size and stromal recruitment in the establishment of successful prostate cancer to bone metastases

This study uses a computational model to show that prostate cancer metastases to bone require optimal cluster size and stromal cell recruitment for successful establishment.