Cancer BiologybioRxivPreprint
The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous proteasome inhibitor resistant disease
R. T. Bishop, A. K. Miller, M. Froid…·D. Basanta
This study uses a hybrid agent-based model to show the bone ecosystem promotes multiple myeloma relapse and the evolution of proteasome inhibitor-resistant disease by providing a protective niche for drug-sensitive cells.
DOI 10.1101/2022.11.13.516335