Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota
C. Gutzeit, E. K. Grasset, D. B. Matthews, P. J. Maglione, G. Magri, G. J. Britton, L. Tomalin, M. Pybus, S. Tejedor Vaquero, P. K. Veeramreddy, R. Tacho-Pinot, A. Martin Nalda, M. Garcia Prat, M. Martinez Gallo, R. Dieli-Crimi, , A. Cerutti
This study shows gut IgA enhances systemic IgG responses to pneumococcal vaccines by regulating antigen translocation and immune activation via the microbiota.
bioRxiv · Apr 29, 2021 · PreprintImmunology