A. Cerutti

HIV-1 infection is associated with depletion of germinal center B cells and a decrease in IgA+ plasma cells in the GI tract

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

The paper identifies a new subset of tonsillar memory B cells that serve as precursors for IgD-secreting plasma cells, contributing to steady-state IgD responses to common antigens.

Gut-associated lymphoid tissue attrition associates with response to anti-α4β7 therapy in ulcerative colitis

This study investigates the mechanism of vedolizumab in ulcerative colitis by analyzing immune cell changes in gut-associated lymphoid tissue and shows that targeting GALT is a novel mechanism of action.

The apicoplast is important for the viability and persistence of Toxoplasma gondii bradyzoites

This study shows that targeting the apicoplast in Toxoplasma gondii bradyzoites reduces their viability, suggesting it as a potential therapeutic target for chronic infections.

Small-molecule Polθ inhibitors provide safe and effective tumor radiosensitization in preclinical models

This study shows that Polθ inhibitors ART558 and ART899 radiosensitize tumor cells without affecting normal fibroblasts, suggesting potential for safe cancer radiotherapy.

Disrupting the plastid-hosted iron-sulfur cluster biogenesis pathway in Toxoplasma gondii has pleiotropic effects irreversibly impacting parasite viability

This study shows that disrupting the SUF iron-sulfur cluster pathway in Toxoplasma gondii severely impairs parasite growth and viability through multiple metabolic and functional defects.

Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota

This study shows gut IgA enhances systemic IgG responses to pneumococcal vaccines by regulating antigen translocation and immune activation via the microbiota.

Toxoplasma TgATG9 is critical for autophagy and long-term persistence in tissue cysts

This study shows that TgATG9 is essential for autophagy and long-term survival of Toxoplasma gondii bradyzoites in tissue cysts.

Differential contribution of two organelles of endosymbiotic origin to iron-sulfur cluster synthesis and overall fitness in Toxoplasma

This study compares the effects of disrupting two Fe-S cluster synthesis pathways in Toxoplasma gondii, showing that plastidic disruption leads to organelle loss and death, while mitochondrial disruption triggers stress resistance.

Xanthomonas transcriptome inside cauliflower hydathodes reveals bacterial virulencestrategies and physiological adaptation at early infection stages

The paper analyzes the transcriptome of Xanthomonas campestris pv. campestris in cauliflower hydathodes three days post-infection, revealing transcriptional reprogramming and early virulence strategies.

Immunoglobulin A Antibody Composition Is Sculpted to Bind the Self Gut Microbiome

The paper investigates IgA antibody reactivity towards gut commensal bacteria in germ-free mice, finding species-level specificity and some strain-level recognition.

Repeated gain and loss of a single gene modulates the evolution of vascular pathogen lifestyles

The paper shows that the gene cbsA acts as a switch for vascular vs. non-vascular pathogenesis in bacteria, with its presence and absence linked to lifestyle evolution.

Anatomy of epithemal hydathodes in four monocotyledon plants of economic and academic relevance

The paper provides a detailed microscopic analysis of hydathodes in four monocot plants, identifying similarities and differences that may inform future studies on their physiology and immunity.

Strain-level differences in gut microbiome composition determine fecal IgA levels and are modifiable by gut microbiota manipulation

The paper identifies Bacteroides ovatus strains that induce IgA production and shows that manipulating these strains can modify gut IgA levels in mice.