C. Cunningham-Rundles

NF-κB Signaling is Required for X-Chromosome Inactivation Maintenance Following T cell Activation

This study shows that NF-κB signaling is necessary for maintaining X-chromosome inactivation in female T cells after activation.

A Germinal Center Checkpoint of AIRE in B Cells Limits Antibody Diversification

This study identifies AIRE as a checkpoint in germinal center B cells that limits antibody diversification by inhibiting AID function, leading to autoimmunity and impaired immune responses.

Atypical memory B cells form a pre-plasmacellular reservoir for steady-state IgD responses to common nasopharyngeal antigens

The paper identifies a new subset of tonsillar memory B cells that serve as precursors for IgD-secreting plasma cells, contributing to steady-state IgD responses to common antigens.

Disease diagnostics using machine learning of immune receptors

The paper develops Mal-ID, a machine learning framework using immune receptor data to diagnose diseases, detecting infections, autoimmune disorders, and vaccine responses.

Gut IgA Enhances Systemic IgG Responses to Pneumococcal Vaccines Through the Commensal Microbiota

This study shows gut IgA enhances systemic IgG responses to pneumococcal vaccines by regulating antigen translocation and immune activation via the microbiota.

Ruxolitinib partially reverses functional NK cell deficiency in patients with STAT1 gain-of-function mutations

This study shows that ruxolitinib partially restores NK cell function in STAT1 GOF patients by reducing STAT1 phosphorylation and improving cytotoxic activity.