Author

M. Genesca

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:flow cytometry· 2 Assay:proteomics· 2

Frequent Co-Authors

M. J. Buzon· 6 shared J. Grau-Exposito· 5 shared D. Perea· 3 shared V. Falco· 2 shared A. Alfranca· 1 shared A. Astorga-Gamaza· 1 shared A. Balazs· 1 shared A. Curran· 1 shared

Activity by Year

2021-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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6 shared papersImmunology

M. J. Buzon

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Combined Dendritic Cell And Anti-TIGIT Immunotherapy Potentiate Trail+ Memory NK Cells Against HIV-1 Infected Cells

I. S. Cerrillo, O. Popova, M. A. Lera, I. Tsukalov, M. C. Mirabent, I. Santos, L. G. Fraile, P. Fuentes, C. D. Arevalo, J. Alcain, N. S. Gaona, M. L. Diez, C. M. Calleja, A. Alfranca, M. Genesca, , E. Martin-Gayo

Combining dendritic cell stimulation with anti-TIGIT antibodies enhances memory NK cell cytotoxicity against HIV-1 infected CD4+ T cells in vitro and in vivo.

bioRxiv · Apr 9, 2024 · PreprintImmunology

Schlafen 12 restricts HIV-1 latency reversal by a codon-usage dependent post-transcriptional block in CD4+ T cells

M. Kobayashi-Ishihara, K. F. Smutna, F. E. Alonso, J. Argilaguet, A. Esteve-Codina, K. Geiger, M. Genesca, J. Grau-Exposito, C. Duran-Castells, S. Rogenmoser, R. Böttcher, J. Jungfleisch, B. Oliva, J. P. Martinez, M. Li, , A. Meyerhans

This study identifies SLFN12 as an HIV-1 restriction factor that inhibits viral replication and reactivation through codon-usage dependent post-transcriptional block in CD4+ T cells.

bioRxiv · Nov 9, 2022Immunology

Zinc pyrithione is a potent inhibitor of PLPro and cathepsin L enzymes with ex vivo inhibition of SARS-CoV-2 entry and replication

J. Kladnik, A. Dolinar, J. Kljun, D. Perea, J. Grau-Exposito, M. Genesca, M. Novinec, M. J. Buzon, I. Turel

bioRxiv · Mar 3, 2022Biochemistry

Identification of HIV-Reservoir Cells with Reduced Susceptibility to Antibody-Dependent Immune Response

A. Astorga-Gamaza, J. Grau-Exposito, J. Burgos, J. Navarro, A. Curran, B. Planas, P. Suanzes, V. Falco, M. Genesca, M. J. Buzon

The paper identifies HIV-infected cells expressing CD32 as having reduced susceptibility to NK-mediated antibody-dependent cell cytotoxicity, contributing to viral persistence.

bioRxiv · Feb 24, 2022Immunology

Entrectinib - a SARS-CoV-2 inhibitor in Human Lung Tissue (HLT) cells

A. Peralta-Garcia, M. Torrens-Fontanals, T. M. Stepniewski, J. Grau-Exposito, D. Perea, V. Ayinampudi, M. Waldhoer, M. Zimmermann, M. J. Buzon, M. Genesca, J. Selent

This study identifies entrectinib as a potential antiviral drug against SARS-CoV-2 using drug repurposing, virtual screening, and in vitro assays in Human Lung Tissue cells.

bioRxiv · Sep 7, 2021Cell Biology

Evaluation of SARS-CoV-2 Entry, Inflammation and New Therapeutics in Human Lung Tissue Cells

J. Grau-Exposito, D. Perea, M. Suppi, N. Massana, A. Vergara, M. J. Soler, J. Blanco, B. Trinite, J. Garcia-Perez, J. Alcami, A. Serrano-Mollar, J. Rosado, V. Falco, M. Genesca, M. J. Buzon

This paper develops a method using primary human lung tissue cells to study SARS-CoV-2 entry, inflammation, and therapeutics, identifying new drug candidates and showing interferons do not modulate ACE2 expression.

bioRxiv · Apr 21, 2021Microbiology