BMI1 regulates human erythroid self-renewal through both gene repression and gene activation
K. E. McGrath, A. D. Koniski, K. Murphy, M. Getman, H. H. An, V. P. Schulz, A. Kim, B. Zhang, T. L. Schofield, J. Papoin, L. Blanc, P. D. Kingsley, C. M. Westhoff, P. G. Gallagher, S. T. Chou, , J. Palis
This study shows BMI1 promotes erythroid self-renewal through both gene repression and activation, offering a strategy to expand immature erythroid precursors for clinical use.
bioRxiv · Feb 2, 2024Cell Biology