A. Kim

Emergence of Functional Heart-Brain Circuits in a Vertebrate

This study tracks the development of heart-brain circuits in larval zebrafish, revealing three stages of functional maturation involving vagal motor, sympathetic, and sensory pathways.

Investigation of expression of genes encoding glycogen degrading enzymes in Gardnerella swidsinskii and identification of reference genes for quantitative real-time PCR

This study identifies reference genes for RT-qPCR in Gardnerella swidsinskii and examines gene expression of glycogen-degrading enzymes under different nutrient conditions.

BMI1 regulates human erythroid self-renewal through both gene repression and gene activation

This study shows BMI1 promotes erythroid self-renewal through both gene repression and activation, offering a strategy to expand immature erythroid precursors for clinical use.

Using a decision tree to predict COVID case numbers: a tutorial for beginners

This paper develops an educational module using decision trees to predict COVID case numbers, aimed at teaching machine learning basics to biology students.

Activation of Protein Kinase R (PKR) Plays a Pro-Viral Role in Mammarenavirus Infected Cells

This study shows that PKR activation can both restrict and enhance LCMV replication, revealing a complex role for PKR in mammarenavirus infection.

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.

Potent Neutralization of Omicron and other SARS-CoV-2 Variants of Concern by Biparatopic Human VH Domains

This study identifies a biparatopic VH domain that neutralizes SARS-CoV-2 VOCs, including Omicron, with high potency in vitro and in a mouse model.

Central role of Prominin-1 in lipid rafts during liver regeneration

This study shows PROM1 is crucial in lipid rafts for liver regeneration by recruiting GP130 and activating the IL6-GP130-STAT3 pathway.

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in Mice

This study shows elevated trimethylamine (TMA) in alcohol-associated hepatitis patients and demonstrates that inhibiting gut microbial TMA production protects mice from ethanol-induced liver injury.

Emerging SARS-CoV-2 Variants of Concern: Spike Protein Mutational Analysis and Epitope for Broad Neutralization

This study identifies a broadly neutralizing antibody fragment and analyzes spike protein mutations in SARS-CoV-2 variants to understand their structural and functional impacts on antibody evasion.

In vitro validation of neoantigen prediction algorithm for developing personalized cancer vaccine therapy

The paper validates a neoantigen prediction algorithm, Neopepsee, by testing its immunogenicity using ELISpot assays on patient-derived samples and compares it to pVACseq.

Structural and Biochemical Rationale for Enhanced Spike Protein Fitness in Delta and Kappa SARS-CoV-2 Variants

This study examines structural and biochemical features of Delta and Kappa SARS-CoV-2 variants, showing increased ACE2 binding and antibody escape, contributing to Delta's dominance.

Structural Analysis of Receptor Binding Domain Mutations in SARS-CoV-2 Variants of Concern that Modulate ACE2 and Antibody Binding

The paper analyzes mutations in the SARS-CoV-2 receptor binding domain to understand their effects on ACE2 and antibody binding in variants of concern.

Single Cell Atlas of Human Dura Reveals Cellular Meningeal Landscape and Insights into Meningioma Immune Response

This study uses single-cell RNA-sequencing to characterize human dura and meningioma, revealing distinct immune microenvironments and TCR overlap between matched samples.

Genetic basis and dual adaptive role of floral pigmentation in sunflowers

The paper identifies a single MYB transcription factor, HaMYB111, as the genetic basis for UV pigmentation diversity in sunflowers and shows its dual role in pollinator attraction and abiotic stress response.

Neutralization of European, South African, and United States SARS-CoV-2 mutants by a human antibody and antibody domains

The paper evaluates an antibody domain's ability to neutralize SARS-CoV-2 variants with mutations in the RBD, showing it neutralizes the triple mutation variant but not others.

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

Neural Basis for Regulation of Vasopressin Secretion by Anticipated Disturbances in Osmolality

The paper identifies distinct neural circuits regulating AVP neuron activity during drinking and eating, revealing presystemic regulation mechanisms for osmolality anticipation.

Ferroportin 3 is a dual-targeted mitochondrial/chloroplast iron exporter necessary for iron homeostasis in Arabidopsis

This study identifies FPN3 as a dual-targeted iron exporter in Arabidopsis mitochondria and chloroplasts, essential for iron homeostasis and growth under iron deficiency.

UHRF1 upregulation mediates exosome release and tumor progression in osteosarcoma

This study shows that UHRF1 upregulation drives exosome release and tumor progression in osteosarcoma by promoting metastasis and cell mobility.

Spiny mice (Acomys) exhibit attenuated hallmarks of aging and rapid cell turnover after UV exposure in the skin epidermis

This study compares UVB-induced skin responses and aging in spiny mice (A. cahirinus) and C57Bl/6 mice, finding increased epidermal turnover and reduced inflammation in spiny mice.

Clusters of bacterial RNA polymerase are biomolecular condensates that assemble through liquid-liquid phase separation

This paper identifies liquid-liquid phase separation as the mechanism organizing RNA polymerase clusters in E. coli, showing they form biomolecular condensates.

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes

This study identifies arginine-vasopressin as a systemic regulator of glucagon secretion, showing its role in counter-regulatory responses to hypoglycemia and its impairment in type 1 diabetes.

FLASH irradiation enhances the therapeutic index of abdominal radiotherapy for the treatment of ovarian cancer

This study shows FLASH irradiation reduces intestinal injury while maintaining ovarian cancer treatment efficacy in preclinical models.

In vivo gene expression analyses provide unique insights on P. vivax gametocytogenesis and chloroquine response

This study uses RNA-seq from P. vivax patient infections to analyze gene expression during gametocytogenesis and chloroquine response, finding independent regulation of male and female gametocytes and minimal chloroquine effect on trophozoites.

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

This study fine-maps genetic loci associated with spontaneous clearance of hepatitis C virus infection, identifying a narrower region in the MHC locus and suggesting subtype-specific effects.