M. Hancock

Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies

This paper demonstrates that deep autoencoders outperform traditional statistical methods in detecting abnormal behavior in zebrafish exposed to toxicants.

Human Cytomegalovirus UL138 Interaction with USP1 Activates STAT1 in infection

This study identifies the UL138-UAF1-USP1 interaction in HCMV that activates STAT1 to regulate latency establishment through innate immune signaling.

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

This paper shows HCMV miR-UL22A downregulates SMAD3 to block TGFβ signaling and limit type I IFN induction during lytic infection.

Fi-score: a novel approach to characterise protein topology and aid in drug discovery studies

The paper introduces Fi-score, a method to characterise protein topology using dihedral angles and B-factors to aid in drug discovery by identifying binding sites and structural importance.