J. Mitchell

γ-aminobutyric acid receptor B signaling drives glioblastoma in females in an immune-dependent manner

This study shows GABA receptor B signaling promotes GBM growth in females through immune mechanisms, with sex-specific effects on survival and treatment outcomes.

Viral microRNA regulation of Akt is necessary for reactivation of Human Cytomegalovirus from latency in CD34+ hematopoietic progenitor cells and humanized mice

This study shows that HCMV miRNAs downregulate Akt to promote reactivation from latency in CD34+ cells and humanized mice.

TINNiK: Inference of the Tree of Blobs of a Species Network Under the Coalescent

TINNiK infers the tree of blobs from a species network under the coalescent model using gene quartet distributions, applied to simulated and empirical data.

Supercontinuum intrinsic fluorescence imaging heralds free view of living systems

This paper introduces a supercontinuum fluorescence imaging technique that enables non-invasive, high-content analysis of living systems across multiple biological processes and species.

Disentangling the Innate Immune Responses of Intestinal Epithelial Cells and Lamina Propria Cells to Salmonella Typhimurium Infection in Chickens

This study compares innate immune responses in 2D and 3D chicken enteroids infected with Salmonella Typhimurium, showing that 3D models better mimic in vivo responses due to the presence of lamina propria cells.

Relating polar bears killed, human presence, and ice conditions in Svalbard 1987-2019

The paper analyzes polar bear kills in Svalbard from 1987-2019, finding a slight decrease in kills and linking them to human presence and ice conditions.

Fisetin Attenuates Cellular Senescence Accumulation During Culture Expansion of Human Adipose-Derived Stem Cells

This study shows fisetin reduces senescence markers in cultured human adipose-derived stem cells while preserving their differentiation potential.

Route of self-amplifying mRNA vaccination modulates the establishment of pulmonary resident memory CD8 and CD4 T cells

This study investigates how different routes of self-amplifying mRNA vaccination affect the establishment of pulmonary resident memory T cells in mice.

Novel insights on obligate symbiont lifestyle and adaptation to chemosynthetic environment as revealed by the giant tubeworm genome

This paper presents the first high-quality genome of Riftia pachyptila, revealing evolutionary adaptations to its chemosynthetic environment and symbiotic lifestyle.

Human cytomegalovirus blocks canonical TGFβ signaling during lytic infection to limit induction of type I interferons

This paper shows HCMV miR-UL22A downregulates SMAD3 to block TGFβ signaling and limit type I IFN induction during lytic infection.

Diet High in Soybean Oil Increases Susceptibility to Colitis in Mice

This study shows that a soybean oil-rich diet increases colitis susceptibility in mice by altering HNF4, gut microbiota, and metabolites.

The recycling endosome protein Rab25 coordinates collective cell movements in the zebrafish surface epithelium

This study shows Rab25 coordinates cytokinetic bridge abscission and cortical actin density in zebrafish gastrula epithelium, affecting cell shape and tissue-scale forces during epiboly.

A heritable androgenic mechanism of female intrasexual competition in cooperatively breeding meerkats

The paper investigates androgen-mediated female intrasexual competition in meerkats, showing that matriarchs' androgen levels influence their behavior and offspring aggression across generations.

Human cytomegalovirus UL7, miR-US5-1 and miR-UL112-3p inactivation of FOXO3a protects CD34+ hematopoietic progenitor cells from apoptosis

This study identifies HCMV proteins and miRNAs that inhibit FOXO3a to prevent apoptosis in CD34+ hematopoietic progenitor cells, aiding viral latency.

Human papillomavirus 16 positive cervical cancer in Guatemala: The D2 and D3 sublineages differ in integration rate and age of diagnosis

This study compares HPV16 D2 and D3 sublineages in Guatemalan cervical cancer samples, finding differences in integration rates, age of diagnosis, and somatic mutation frequency.

Diverse cell junctions with unique molecular composition in tissues of a sponge (Porifera)

This study identifies unique molecular composition and distribution of cell junctions in sponge tissues, suggesting early evolution of adhesion roles and distinct structural features.

Metabolic dysregulation of the lysophospholipid/autotaxin axis in the chromosome 9p21 gene SNP rs10757274

The paper identifies metabolic dysregulation of lysophospholipid/autotaxin pathways linked to a CHD risk SNP, showing altered lipid metabolism and enzyme expression in multiple models.

The Autoimmune Susceptibility Gene, PTPN2, Restricts Expansion of a Novel Mouse Adherent-Invasive E. coli

This study shows PTPN2 deficiency in mice promotes expansion of a novel adherent-invasive E. coli that worsens colitis.

HCMV miR-US22 down-regulation of EGR-1 regulates CD34+ hematopoietic progenitor cell proliferation and viral reactivation

This study shows HCMV miR-US22 down-regulates EGR-1, reducing CD34+ HPC proliferation and colony formation, and preventing viral reactivation.

Distinguishing Closely Related Pancreatic Cancer Subtypes In Vivo by 13C Glucose MRI without Hyperpolarization

The paper distinguishes closely related pancreatic cancer subtypes in vivo using 13C glucose MRI without hyperpolarization by detecting metabolic differences through tensor decomposition.

Gibberellin response in the embryo epidermis regulates germination uniformity in response to seed priming

The paper identifies a molecular signaling pathway in the embryo epidermis that enhances germination uniformity through gibberellin response, influenced by hydropriming.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

The paper investigates how T-dependent B cells produce antibodies that form a high-avidity multivalent complex with Plasmodium falciparum CSP, revealing structural and immunological insights.

Genetic Variation In Adaptability And Pleiotropy In Budding Yeast

The paper quantifies genetic variation in adaptability and pleiotropy in budding yeast offspring, finding that initial genotype affects adaptability and pleiotropy, with heritable differences arising from natural variation.