M. Heine

Homeostatic feedback between lysosomal mTORC1 and mTORC2-AKT signaling controls nutrient uptake in brown adipose tissue

The paper shows that LAMTOR2 deletion in adipocytes causes insulin-independent AKT hyperphosphorylation, leading to increased glucose and fatty acid uptake and glycogen storage in brown adipose tissue.

High-throughput super-resolution single particle trajectory analysis reconstructs organelle dynamics and membrane re-organization

This paper introduces a computational method to analyze high-throughput super-resolution single-particle trajectories, enabling reconstruction of organelle dynamics and membrane reorganization.

Reconstructing wells from high density regions extracted from super-resolution single particle trajectories

The paper develops statistical methods to reconstruct potential wells from super-resolution single particle trajectories, applying them to analyze voltage-gated calcium channels and phospholipids on neuronal cells.

Neuronal receptors display cytoskeleton-independent directed motion on the plasma membrane

The paper identifies a subpopulation of EphB2 receptors that move directionally between synapses in the plasma membrane without cytoskeleton dependence, but requiring cholesterol and neuronal activity.