M. Lu

A Multi-Layered Atlas of Spatial Regulatory Programs and Therapeutic Vulnerabilities in Glioblastoma

This paper constructs a spatial regulatory atlas of glioblastoma by integrating transcriptional data with drug target predictions to identify niche-specific therapeutic vulnerabilities.

A Host Enzyme Reduces Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) by Inactivating Intestinal Lipopolysaccharide

This study shows that AOAH inactivates intestinal LPS, reducing MASLD by preventing hepatic lipid accumulation and altering lipid metabolism gene expression.

Ancestral SARS-CoV-2 immune imprinting persists on RBD but not NTD after sequential Omicron infections

The paper examines how sequential Omicron infections affect ancestral SARS-CoV-2 immune imprinting, finding that it persists on the RBD but not the NTD.

Calorie Restriction Induces Degeneration of Neurons with Mitochondrial DNA Depletion by Altering ER-Mitochondria Calcium Transfer

This study shows that calorie restriction exacerbates neuronal degeneration in mtDNA-depleted neurons by increasing ER-mitochondria calcium transfer, suggesting CR may not be beneficial for mitochondrial epilepsy.

Exploring Integrin α5β1 as a Potential Therapeutic Target for Pulmonary Arterial Hypertension: Insights from Comprehensive Multicenter Preclinical Studies

The study identifies integrin α5β1 as a key driver of pulmonary vascular remodeling in PAH and shows its inhibition improves hemodynamics and RV function in preclinical models.

Clostridium ablates tumors by degrading collagen mesh andinducing ferroptosis

This paper describes a Clostridium strain that degrades collagen and induces ferroptosis in tumors, leading to effective tumor destruction in mice.

Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid.

The paper investigates RA's limited effect on primary neuroblastoma tumors but efficacy in clearing bone marrow cells, identifying BMP signaling as a key determinant of cell fate and RA sensitivity.

Genetic architecture underlying response to the fungal pathogen Dothistroma septosporum in lodgepole pine, jack pine, and their hybrids

This study identifies genetic factors underlying resistance to Dothistroma septosporum in lodgepole pine, jack pine, and their hybrids using genome-wide association analysis.

Conditional c-MYC activation in catecholaminergic cells drives distinct neuroendocrine tumors: neuroblastoma vs somatostatinoma

This study creates two mouse models with conditional c-MYC activation in specific cell types, leading to distinct neuroendocrine tumors resembling human neuroblastoma and somatostatinoma.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

Guanylate cyclase activity of TIR1/AFB auxin receptors mediates rapid auxin responses

The paper shows TIR1/AFB auxin receptors have both adenylate and guanylate cyclase activities, mediating transcriptional reprogramming and rapid Ca2+-dependent growth responses.

A novel rotavirus reverse genetics platform supports flexible insertion of exogenous genes and enables rapid development of a high-throughput neutralization assay

This paper develops a rotavirus reverse genetics platform enabling exogenous gene insertion and a high-throughput neutralization assay to study immune responses.

Targeted mutations in IFNα2 improve its antiviral activity against various viruses

The paper identifies critical antiviral residues in IFN subtypes and designs improved IFN molecules with enhanced antiviral activity against HIV and HBV.

Human receptive endometrial assembloid for deciphering the implantation window

This study develops a human endometrial assembloid model that mimics the receptive endometrium during the implantation window, showing structural and molecular features and hormone responsiveness.

Structural basis for auto-inhibition and activation of a short prokaryotic Argonaute associated TIR-APAZ defense system

The paper determines cryo-EM structures of SPARTA in different states to elucidate its auto-inhibition and activation mechanisms.

An integrated single-cell RNA-seq map of human neuroblastoma tumors and preclinical models uncovers divergent mesenchymal-like gene expression programs.

The paper compares mesenchymal-like gene expression programs in neuroblastoma preclinical models and patient tumors using single-cell RNA-seq and identifies chemotherapy-induced changes in PDX and GEMM.

Multi-omics of the gut microbial ecosystem in the immunotherapy resistance in microsatellite instability-high gastrointestinal cancer patients

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

Comparative transcriptomics reveals divergence in pathogen response gene families amongst 20 forest tree species

This study uses RNA-seq data from 20 forest tree species to analyze gene family divergence, identifying shared whole genome duplication events and rapid evolution in pathogen response genes.

An intact amber-free HIV-1 system for in-virus protein bioorthogonal click labeling that delineates envelope conformational dynamics

This paper develops an amber-free HIV-1 system for in-virus protein labeling, enabling smFRET analysis of Env conformational dynamics without disrupting structural integrity.

Broadly effective ACE2 decoy proteins protect mice from lethal SARS-CoV-2 infection

This paper develops two ACE2 decoy proteins that neutralize diverse SARS-CoV-2 variants and protect mice from lethal infection with high survival rates.

How useful is genomic data for predicting maladaptation to future climate?

The paper evaluates two methods for predicting population maladaptation to climate change using genomic data and finds they outperform climatic distances but have limited predictive consistency across future climates.

B3GALT6 Promotes Dormant Breast Cancer Cell Survival and Recurrence by Enabling Heparan Sulfate-Mediated FGF Signaling

The paper identifies B3GALT6 as a key regulator of dormant breast cancer cell survival and recurrence through heparan sulfate-mediated FGF signaling.

Ribonucleotide Reductase Subunit Switching in Hepatoblastoma Drug Response and Relapse

This study identifies RRM2 and RRM2B as key players in hepatoblastoma progression and drug response, showing their dynamic switching and impact on relapse.

SGC-CLK-1 (CAF-170) a chemical probe for the Cdc2-Like kinases CLK1, CLK2, and CLK4

This paper identifies and characterizes SGC-CLK-1, a potent inhibitor of CLK1, CLK2, and CLK4, showing its selectivity and effects on SR protein phosphorylation and localization.

Exploring the interaction between immune cells in testicular microenvironment of azoospermia combining RNA-seq and scRNA-seq

The paper analyzes RNA-seq and scRNA-seq datasets to identify immune cell interactions in the testicular microenvironment of azoospermia patients, finding altered monocyte/macrophage signaling patterns.

Reconceptualizing beta diversity: a hypervolume geometric approach

This paper introduces a geometric hypervolume approach to measure beta diversity, accounting for non-additivity and species interactions, and applies it to address ecological questions.

O-GlcNAcylation promotes YTHDF1 cytosolic localization and colorectal cancer tumorigenesis

This study shows O-GlcNAcylation of YTHDF1 enhances its cytosolic localization and promotes colorectal cancer by increasing c-Myc expression.

A continental scale analysis reveals widespread root bimodality

The paper analyzes continental-scale root data and finds widespread root bimodality, with secondary root biomass peaks deeper than 60cm, linked to soil nitrogen content and vegetation type.

Soil depth governs microbial community assembly and enzymatic activity in extreme environments

The paper examines how soil depth influences microbial community structure and enzymatic activity in extreme desert environments, finding that depth-related environmental heterogeneity drives these patterns.

Neural Network-Derived Potts Models for Structure-Based Protein Design using Backbone Atomic Coordinates and Tertiary Motifs

This paper combines neural network models with tertiary motif data to improve protein design by generating Potts energy models that predict folding and energetics.