Pharmacology & ToxicologybioRxivPreprint
Facilitation by a hERG blocker is induced by pore opening and operates by pore reopening
K. Furutani, R. Kawano, M. Ichiwara…·S. Kita
This study investigates how nifekalant, a hERG blocker, facilitates hERG channel activation through pore opening rather than voltage sensors.
DOI 10.1101/2022.05.26.493575