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M. J. Bocek

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Cell Biology· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1

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J. C. Saldivar· 1 shared K. A. Cimprich· 1 shared S. Hamperl· 1 shared

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2017-2017 · peak 1/yr

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1 shared paperCell Biology

J. C. Saldivar

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Cell BiologybioRxivJun 26, 2017

DNA Replication Modulates R-loop Levels to Maintain Genome Stability

S. Hamperl, J. C. Saldivar, M. J. Bocek, K. A. Cimprich

This study shows that DNA replication orientation affects R-loop formation, with the replisome reducing R-loops in co-directional conflicts but promoting them in head-on conflicts, leading to genome instability.

DOI 10.1016/j.cell.2017.07.043

humanDNA methylation

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