Pharmacology & ToxicologybioRxiv
A unifying model to predict variable drug response for personalised medicine
M. van der Lee, W. G. Allard, R. H. A. M. Vossen…·S. Y. Anvar
The paper introduces a continuous scale model using full gene sequencing and neural networks to predict CYP2D6 enzyme activity, explaining 79% of interindividual variability in drug response.
DOI 10.1126/scitranslmed.abf3637