Asparagine availability controls B cell homeostasis
Y. F. Yazicioglu, E. Marin, K. Bentkowska, H. Andrew, R. Mitchell, Z. Y. Wong, J. Fergusson, M. Borsa, J. C. Johnstone, M. Ali, B. Kronsteiner, I. L. Furlani, J. I. MacRae, M. J. Devine, M. Coles, , A. Clarke
The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.
bioRxiv · Apr 3, 2023Immunology