Author

C. Buckley

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Physiology· 2 Cell Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:differential expression· 3 Organism:rat· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

C. Wilson· 3 shared M. D. Lee· 3 shared X. Zhang· 3 shared J. G. McCarron· 2 shared M. Coles· 2 shared M. MacDonald· 2 shared A. Clarke· 1 shared A. Filer· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersPhysiology

C. Wilson

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Increased TRPV4 channel expression enhances and impairs blood vessel function in hypertension

X. Zhang, C. Buckley, M. D. Lee, M. MacDonald, C. Wilson, J. G. McCarron

This study shows that increased TRPV4 channel expression in endothelial cells both enhances and impairs vascular function in hypertension, leading to altered Ca2+ signaling and vascular reactivity.

bioRxiv · Mar 27, 2024Physiology

A longitudinal single-cell therapeutic atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease

T. Thomas, C. Rich-Griffin, M. Pohin, M. Friedrich, D. Aschenbrenner, J. Pakpoor, A. Jainarayanan, A.-I. Voda, R. Sanches Peres, E. Nee, D. Sathananthan, D. Kotliar, J. Turner, S. Nayar, F. Zhang, , C. Buckley

This study creates a therapeutic atlas of anti-TNF treatment in IBD, showing disease- and therapy-specific cellular changes and identifying IFN signalling as a potential target for JAK inhibition.

bioRxiv · May 5, 2023Immunology

Asparagine availability controls B cell homeostasis

Y. F. Yazicioglu, E. Marin, K. Bentkowska, H. Andrew, R. Mitchell, Z. Y. Wong, J. Fergusson, M. Borsa, J. C. Johnstone, M. Ali, B. Kronsteiner, I. L. Furlani, J. I. MacRae, M. J. Devine, M. Coles, , A. Clarke

The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.

bioRxiv · Apr 3, 2023Immunology

An optimised method for bacterial nucleic acid extraction from positive blood culture broths for whole genome sequencing, resistance phenotype prediction and downstream molecular applications

M. Bauer, A. M. Peri, L. Luftinger, S. Beisken, H. Bergh, B. M. Forde, C. Buckley, T. Cuddihy, P. Tan, D. Paterson, D. M. Whiley, P. N. A. Harris

This paper optimizes DNA extraction from blood culture broths for whole genome sequencing and resistance prediction, showing high accuracy for common pathogens and potential for rapid diagnostics.

bioRxiv · Jun 30, 2022 · PreprintMicrobiology

Mitochondrial ATP production is required for endothelial cell control of vascular tone

C. Wilson, M. D. Lee, C. Buckley, X. Zhang, J. McCarron

This study shows that mitochondrial ATP production is essential for endothelial cell regulation of vascular tone across species, affecting calcium activity and nitric oxide signaling.

bioRxiv · Sep 14, 2021Physiology

Disrupted Endothelial Cell Heterogeneity and Network Organization Impairs Vascular Function in Prediabetic Obesity

C. Wilson, X. Zhang, M. D. Lee, M. MacDonald, H. Heathcote, N. Alorfi, C. Buckley, S. Dolan, J. G. McCarron

This study shows that disrupted endothelial cell heterogeneity and network organization in prediabetic obesity impair vascular function by altering calcium signaling and communication patterns.

bioRxiv · May 7, 2020Cell Biology