Author

A. Clarke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Cell Biology· 3 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:host-pathogen & immune response· 3 Research Focus:cell signaling & trafficking· 2 Assay:behavioral assay· 1 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Kronsteiner· 2 shared E. Giniger· 2 shared E. Marin· 2 shared H.-Y. Fang· 2 shared M. Ali· 2 shared M. Dustin· 2 shared S. Dunachie· 2 shared Y. F. Yazicioglu· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersImmunology

B. Kronsteiner

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

Asparagine availability controls B cell homeostasis

Y. F. Yazicioglu, E. Marin, K. Bentkowska, H. Andrew, R. Mitchell, Z. Y. Wong, J. Fergusson, M. Borsa, J. C. Johnstone, M. Ali, B. Kronsteiner, I. L. Furlani, J. I. MacRae, M. J. Devine, M. Coles, , A. Clarke

The paper shows asparagine metabolism is critical for B cell function and germinal centre homeostasis, with Asn deprivation impairing survival, proliferation, and immune responses.

bioRxiv · Apr 3, 2023Immunology

Changes in local interaction rules during ontogeny underlie the evolution of collective behavior

A. Paz, K. J. Holt, A. Clarke, A. Aviles, B. Abraham, A. C. Keene, E. R. Duboue, Y. Fily, J. E. Kowalko

The paper studies how local interaction rules change during development and evolution in Mexican tetra fish, showing surface fish develop schooling behavior through alignment and attraction, while cavefish lose schooling behavior.

bioRxiv · Mar 28, 2023Evolutionary Biology

LAT1 enables T cell activation under inflammatory conditions: a new therapeutic target for rheumatoid arthritis

J. Ogbechi, H. L. Wright, S. Balint, L. Topping, K. Zec, I.-S. Huang, E. Pantazi, M. Swart, D. Windell, E. Marin, M. F. Wempe, H. Endou, A. M. Thomas, A. Filer, T. W. Stone, , R. Williams

This study shows LAT1 is critical for T cell activation in rheumatoid arthritis and identifies it as a therapeutic target, with a LAT1 inhibitor effective in mouse models.

bioRxiv · Dec 20, 2022 · PreprintImmunology

Dynamic mitochondrial transcription and translation in B cells control germinal centre entry and lymphomagenesis

Y. F. Yazicioglu, E. M. Marin, C. Sandhu, S. Galiani, I. G. A. Raza, M. Ali, B. Kronsteiner, E. Compeer, M. Attar, S. Dunachie, M. Dustin, A. Clarke

This study shows that mitochondrial transcription and translation in B cells are critical for germinal centre entry and lymphomagenesis, with TFAM playing a key role.

bioRxiv · Jul 19, 2022 · PreprintImmunology

Plasma iron controls neutrophil production and function

J. N. Frost, S. K. Wideman, A. E. Preston, M. R. Teh, Z. Ai, L. Wang, A. Cross, N. White, Y. Yazicioglu, M. Bonadonna, A. Clarke, A. E. Armitage, B. Galy, I. A. Udalova, H. Drakesmith

The paper shows hypoferremia reduces neutrophil production and alters their function, while increasing NETosis, and suggests targeting hepcidin could modulate innate immunity.

bioRxiv · Mar 17, 2022Immunology

Computational simulations reveal that Abl activity controls cohesiveness of actin networks in growth cones

A. Chandrasekaran, A. Clarke, P. G. McQueen, H.-Y. Fang, G. A. Papoian, E. Giniger

The paper uses computational simulations to show that Abl activity regulates actin network cohesiveness in axons by modulating Arp2/3 activity.

bioRxiv · Nov 1, 2021Cell Biology

A zebrafish reporter line reveals immune and neuronal expression of endogenous retrovirus.

H. A. Rutherford, A. Clarke, E. V. Chambers, J. J. Petts, E. G. Carson, H. Isles, A. Duque-Jaramillo, S. A. Renshaw, J.-P. Levraud, N. Hamilton

This study creates a zebrafish ERV reporter line to identify tissues expressing endogenous retroviruses, revealing their presence in T cells and neurons.

bioRxiv · Jan 21, 2021Cell Biology

Abl signaling shapes the intrinsic fluctuations of actin to direct growth of a pioneer axon in Drosophila

A. Clarke, P. McQueen, H.-Y. Fang, R. Kannan, V. Wang, E. McCreedy, S. Wincovitch, E. Giniger

This study shows Abl signaling modulates actin fluctuations in Drosophila pioneer axons to drive directed growth by promoting protrusions in leading intervals and collapsing them in lagging intervals.

bioRxiv · Jan 4, 2019Cell Biology