Total Biosynthesis of Triacsin Featuring an N-hydroxytriazene Pharmacophore
A. Del Rio Flores, F. F. Twigg, Y. Du, W. Cai, D. Q. Aguirre, M. Sato, M. J. Dror, M. Narayanamoorthy, J. Geng, N. A. Zill, W. Zhang
This study identifies the enzymes responsible for biosynthesizing the N-hydroxytriazene pharmacophore in triacsins, revealing two ATP-dependent enzymes involved in consecutive N-N bond formation.
bioRxiv · May 12, 2021Biochemistry