Hepatic JNK-mediated bile acid homeostasis regulates liver cancer through PPARα
E. Manieri, L. Esteban-Lafuente, E. Rodriguez, L. Leiva-Vega, C. Chen, F. J. Cubero, T. Barrett, J. Cavanagh-Kyros, D. Seruggia, M. J. Monte, J. J. Marin, R. R. J. Davis, A. Mora, G. Sabio
This study shows that hepatic JNK deficiency alters bile acid metabolism and promotes liver cancer via PPARα activation in mice on a high-fat diet.
bioRxiv · Sep 29, 2019 · PreprintCancer Biology