Spermidine/spermine N1-acetyltransferase controls tissue-specific regulatory T cell function in chronic inflammation
T. Neuwirth, D. Malzl, K. Knapp, P. Tsokkou, L. Kleissl, A. Redl, C. Freystaetter, N. Marella, A. P. Kutschat, E. Ponweiser, A. Haschemi, D. Seruggia, J. Menche, E. F. Wagner, G. Stary
The paper identifies SAT1 as a marker of skin-specific Treg dysfunction in TH17-mediated inflammation and shows targeting SSAT can rescue Treg function in a mouse model.
bioRxiv · Mar 25, 2024 · PreprintImmunology