A. Mora

Lack of p38 activation in T cells increases IL-35 production and protects against obesity by promoting thermogenesis

This study shows that inhibiting p38 in T cells increases IL-35 production, which enhances thermogenesis and protects against obesity.

D-mannose ameliorates age-associated cellular senescence in the bladder urothelium and NLRP3/Gasdermin/IL-1β -driven pyroptotic epithelial cell shedding

This study shows that D-mannose reduces age-related bladder urothelial senescence and pyroptotic cell shedding in mice by improving autophagy and reversing SASP.

FOXA2 controls the anti-oxidant response in FH-deficient cells

This study identifies FOXA2 as a key transcription factor regulating the anti-oxidant response in FH-deficient cells, independent of NRF2, and highlights its role in metabolic rewiring.

Studies on the interaction of three lytic bacteriophages with a wide collection of Escherichia coli strains implicated in swine enteric colibacillosis

This study evaluates three bacteriophages against ETEC and STEC strains from swine, finding they have narrow lytic spectra and some exhibit unique receptor recognition.

The Role of EBP50 in Regulating Endothelial-To-Mesenchymal Transition in Pulmonary Hypertension

This study shows EBP50 downregulation promotes EndMT in pulmonary hypertension by increasing Snail, Zeb1, and Slug expression, and mesenchymal markers, while reducing cell proliferation and barrier function.

A comparative analysis reveals irreproducibility in searches of scientific literature

This study shows that search results from different databases vary by location and environment, highlighting the need for more consistent search practices in scientific research.

Hepatic JNK-mediated bile acid homeostasis regulates liver cancer through PPARα

This study shows that hepatic JNK deficiency alters bile acid metabolism and promotes liver cancer via PPARα activation in mice on a high-fat diet.