Dysregulated Transferrin Receptor Disrupts T Cell Iron Homeostasis to Drive Inflammation in Systemic Lupus Erythematosus
K. Voss, A. Young, K. N. Gibson-Corley, A. E. Sewell, E. Krystofiak, J. H. Bashum, W. N. Beavers, A. Sugiura, E. P. Skaar, M. J. Ormseth, J. Rathmell
This study shows that dysregulated CD71 in T cells increases iron uptake, disrupts mitochondrial function, and drives inflammation in SLE, with CD71 blockade improving outcomes.
bioRxiv · Nov 25, 2021 · PreprintImmunology